Dr. Kevin Lam* Dr. Wesley Drew Chapman * Dr. Sean Dunleavy
Dr. Patrick Bartholomew * Dr. Lauren Pelucacci * Dr. Sahiba Singh
Dr. Jake Powers * Dr. John Crist * Dr. Isin Mustafa * Dr. Lori DeBlasi
What Gout Affects
Gout is a crystalline or inflammatory form of arthritis. Gout develops when there is too much uric acid in the bloodstream. This dissolved uric acid then comes out of the bloodstreams and forms spike-like crystals in the joints or soft tissues. The high levels of serum urate cause painful, swollen, stiff joints, it most commonly appears as sudden swelling at the base of the big toe.
If you have gout, talk to your doctor about
Chronic Kidney Disease and Kidney Stones
Uric acid crystals build up in the kidneys and can cause problems. This can range from reduced function to kidney failure. Although the damage is progressive, the appropriate treatment can slow down its progress. A study showed that people with gout have a 78% higher risk of moderate kidney disease. This condition typically has no symptoms. It is estimated that 1 in 5 people with gout can have kidney stones that form when uric acid crystals settle in the organs and block the urinary tract. The higher the uric acid level, the higher the risk, the study found.
Heart Disease and Stroke
Studies also reveal that gout is associated with an increased risk of several types of cardiovascular disease such as irregular heartbeat or atrial fibrillation, heart attack, and heart failure. It was found that adults 65 and older at an increased risk of heart attack compared with those without gout. Gout also increases the risk for peripheral vascular disease and stroke.
Women with gout are 70% more likely to develop diabetes while it increases the risk my 20% for men.
Out-of-control chronic gout can be painful, unpredictable, and cause permanent damage. Even after gout flares end, uric acid crystals from gout stay in your body, settle in your joints, and damage your bones.
Untreated gout can lead to worsening pain and joint damage. Gout comorbidities include sleep problems, mental health problems, diabetes, heart disease, kidney disease, tophi, and bone loss.
For those with kidney disease and can’t take the usual gout medications, Krystexxa can treat your condition without harming your kidneys.
Family Foot & Leg Center is one of the few Krystexxa Infusion Centers in Southwest Florida. If you have chronic gout, contact us at (239) 430 3668 to find out more information.
CHD, coronary heart disease; PAD, peripheral arterial disease; PVD, peripheral vascular disease; sUA, serum uric acid
Negative effects of gout on the heart, kidneys, joints
Some people may experience recurrent gout. If left untreated, there can be deposits of urate crystals under the skin nodules called tophi, commonly found in the fingers, hands, feet, Achilles tendon, and the backs of the ankles. Urate crystals may also collect in the urinary tract of people with gout, eventually causing kidney stones.
People with gout have also been found to have higher risk of cardiovascular disease. Hyperuricemia is associated with endothelial dysfunction, which may contribute to risk of heart disease.
How are purines turned to uric acid?
The purine nucelotides adenine and guanine are broken down to form uric acid.
People who have difficulty metabolizing purines (such as those with gout or hyperuricemia) are advised to limit the consumption of high-purine food and drinks. If the level of purines in the body is more than the ability of the body to process them, too much uric acid builds up in the bloodstream. This condition is called hypeuricemia and aside from gout, this can also cause kidney stones. Normally, uric acid is disposed via the kidneys. The human body cannot oxidize uric acid to the more soluble compound allantoin due to the lack of uricase enzyme.
Uricase converts uric acid to allantoin, which is more soluble than uric acid and passes harmlessly from the body. Uricase is an enzyme that catalyzes the oxidation of uric acid to 5-hydroxyisourate and hydrogen peroxide (H2O2). Subsequent hydrolysis and decarboxylation leads to the formation of allantion. During evolution, humans have lost the ability to produce the enzyme uricase. This loss of uricase activity along with the lifestyle and eating habits of today renders humans prone to urate crystal deposition and gout.
How do medications help people with gout?
Gout medications can be used to treat acute flare-ups and prevent future gout attacks. Some can also reduce the risk of gout complications such as the development of tophi.
Medications that block uric acid production such as allopurinol (Aloprim) and febuxostat (Uloric) limit the amount of uric acid that the body makes to lower the blood uric acid levels. However, these can cause side effects such as reduced liver function and heart-related problems. Even with oral medication, people with uncontrolled gout can have a difficulty getting rid of uric acid.
Krystexxa works differently than the above oral gout medicines. Krystexxa is the only gout treatment that converts uric acid into water-soluble substance called allantoin. Allantion is very soluble and is readily excreted through urine. The uric acid level then reaches a point in which uric acid crystals can dissolve. New uric acid crystal buildup also stops forming, thus taking control of gout.
Proud to be a Krystexxa infusion center to help our patients get rid of gout from the body.
See us now to see if you are a candidate.
For adults with chronic gout that hasn’t been controlled with other treatments
IF YOU HAVE MORE THAN ONE FLARE A YEAR, IT MAY BE TIME TO STEP UP YOUR GOUT TREATMENT
Recurrent gout flares may be your body’s way of telling you that oral medicines aren’t doing enough to lower your uric acid level and prevent the harmful effects of out-of-control chronic gout. KRYSTEXXA has been helping gout patients for nearly 10 years. Studies show that one IV treatment every other week for about 6 months is all you may need to take control.
KRYSTEXXA WORKS DIFFERENTLY THAN ORAL GOUT MEDICINES TO QUICKLY DISSOLVE GOUT BUILDUP
KRYSTEXXA has a different way of lowering uric acid levels, which is the key to stopping gout flares. In about 6 months, it can safely and effectively remove years of uric acid crystal buildup from your joints. KRYSTEXXA is also a safe option for uncontrolled gout even if you have kidney disease.
IMPORTANT SAFETY INFORMATION
What is the most important information I should know about KRYSTEXXA (pegloticase)?
Serious allergic reactions may happen in some patients who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.
Before you receive KRYSTEXXA, tell your doctor if you:
Know you have G6PD deficiency
Ever had any heart problems or high blood pressure
Are pregnant or planning to become pregnant. It is not known if KRYSTEXXA will harm your unborn babyAre breastfeeding or plan to breastfeed. It is not known if KRYSTEXXA passes into your breast milk
Tell your doctor about all the medicines you take. Do not take any other uric acid lowering drug, such as allopurinol or febuxostat (Uloric®), while taking KRYSTEXXA.
Prior to your treatment with KRYSTEXXA, your doctor may give you medicine to help reduce your chance of getting a reaction. Take these medicines as directed by your doctor or nurse. Your doctor will also test your uric acid levels prior to each treatment to monitor your response to KRYSTEXXA.
THE MORE GOUT BUILDS UP, THE MORE HARM IT CAN DO
Out-of-control chronic gout can be painful, unpredictable, and cause permanent damage. Even after gout flares end, uric acid crystals from gout stay in your body, settle in your joints, and damage your bones. Uric acid crystals can also build up in vital organs like kidneys. If you have gout and kidney disease, it’s important to take control of gout because gout can lead to kidney disease progression.
Unlike medicines you take long term, KRYSTEXXA is given every 2 weeks for about 6 months.
THE MORE GOUT BUILDS UP, THE MORE HARM IT CAN DO
KNOW YOUR OPTIONS: TALK TO A GOUT SPECIALIST
HEAR IT ALL FROM REAL KRYSTEXXA PATIENTS
EVEN IF YOU’RE MANAGING YOUR SYMPTOMS, YOUR CHRONIC GOUT MAY BE OUT OF CONTROL
Out-of-control chronic gout is gout that continues to flare up even though you’re taking a daily oral medication to lower your uric acid level and medications like anti-inflammatories to treat the symptoms of your flares. Experiencing recurrent gout flares while on oral gout medicines is one sign your gout is chronic and out of control.
OUT-OF-CONTROL CHRONIC GOUT IS ALSO REFERRED TO AS:
- Uncontrolled gout
- Recurring gout
- Advanced gout
- Refractory gout
- Tophaceous gout
- Chronic gouty arthritis
- Persistent gout
FFLC Gout Institute
We welcome you as a patient to our podiatry practice in Florida. We currently have 8 locations across Lee, Collier, and Charlotte counties, We are grateful that you have chosen us as your complete foot and lower leg care center.
how is gout treated?
Gout can be effectively treated and managed with medical treatment and self-management strategies.
- Manage the pain of a flare
- Prevent future flares.
- Prevent tophi and kidney stones from forming
In addition to medical treatment, you can manage your gout with self-management strategies. Self-management is what you do day to day to manage your condition and stay healthy, like making healthy lifestyle choices. The self-management strategies described below are proven to reduce pain and disability, so you can pursue the activities important to you.
- Eat a healthy diet.
- Avoid foods high in purines such as red meat, organ meat, and seafood
- limit alcohol intake, particularly beer
- Exercise regularly, engaging in low-impact activities such as cycling, walking, swimming
- Maintain ideal weight
- Consult your doctor and follow the recommended treatment plan
- Protect your joints from injuries that can worsen your condition
We have several locations from Collier, Lee, & Charlotte Counties to serve your foot and ankle needs:
Part of Family Foot and Leg Center, PA
Why do I have gout?
Uric acid levels spike when the body breaks down purines, which are found in certain food such as red meat, seafood, and organ meats as well alcohol, particularly beer and fruit drinks. Urate crystals then develop and build up in your joints. These sharp, needle-like crystals lead to the gout pain.
What are the symptoms of gout?
- Swelling of the joint, commonly the big toe
- Very painful joint
- Redness and inflammation
- Limited range of motion
What are the treatments for gout?
The treatment of gout aims to lessening your pain and preventing gout flare-ups in the future. See your physician for a thorough evaluation and treatment plan.
Our team at the Gout Institute, a part of Family Foot and Leg Center, P.A. work together to provide the best gout treatment for your specific needs.
Get relief from your gout.
Schedule for an evaluation today at the Gout Institute at Family Foot and Leg Center, P.A.
8 locations throughout Lee, Collier and Charlotte Counties to get you back on your feet
*East Naples / Marco Island
*Fort Myers @International Blvd
*Fort Myers @Colonial Blvd
Call Today: 239 430 3668 (FOOT)
Self Service # 844-889-1725
Fax: 239 692 9436